Thanksgiving is all about gathering with your loved ones and sharing a delicious meal. These high protein Thanksgiving casseroles are my favorite thing to serve during Thanksgiving.

While turkey is often the protagonist in this meal, the side dishes can make or break your tasty meal.

Not only are these casseroles comforting in a meal, but they are also so easy to make. And, if you’ve planned a Thanksgiving dinner, you know that the more efficient the process, the less stress you’ll end up having (although it never goes away).

Here, I have for you 23 high-protein Thanksgiving casseroles. These are designed to be crowd pleasers, while still offering a satisfying and healthy meal.

1. High Protein Spaghetti Casserole

Source: cushyspa.com

I know that spaghetti might not be a traditional Thanksgiving dish, but you are going to want to hear me out with this casserole dish. It combines ground beef, a rich-tomato base sauce, and creamy layers of cheese with spaghetti noodles, all baked to perfection.

This recipe is a comforting classic with a healthy twist. It’s a great option if you have picky eaters at home and you don’t know what to give them during the holidays.

Per Serving:

• Calories: 605
• Fats: 22g
• Protein: 38g
• Carbs: 65g
• Fiber: 6.4g
• Sugar: 14g

2. Fajita Chicken Casserole

Source: cushyspa.com

Bring some zesty, vibrant flavor to your Thanksgiving table with this fajita chicken casserole. This dish features tender, juicy chicken breasts with a bold fajita spice blend.

And, it’s layers with colorful bell peppers and onions, and topped with gooey, melted mozzarella cheese. The best thing is that it has less than 8 grams of net carbs, making it a great option for those following a keto lifestyle.

Per Serving:

• Calories: 363
• Fats: 13g
• Protein: 49g
• Carbs: 10g
• Fiber: 2.5g
• Sugar: 3.8g

3. Chicken Burrito Casserole

Love the flavors of a burrito but don’t want to spend all that time rolling each one (especially before a Thanksgiving dinner)? This chicken burrito casserole is the perfect solution.

It combines all the things you love about a burrito: seasoned chicken, brown rice, black beans, corn, and cheese. And, it’s all made in a convenient one-dish bake.

Per Serving:

• Calories: 521
• Fats: 24g
• Protein: 34g
• Carbs: 43g
• Fiber: 8.9g
• Sugar: 4.1g

4. Chicken Parmesan Casserole

Transform the classic Italian-American favorite into an easy-to-make casserole that’s perfect for your large family or group of friends. This chicken Parm has everything.

It has diced chicken, savory marinara sauce, and rigatoni pasta, all topped with a crunchy layer of Panko breadcrumbs and melted mozzarella and Parmesan cheese.

Did your mouth start to water?

Per Serving:

• Calories: 503
• Fats: 11g
• Protein: 37g
• Carbs: 61g
• Fiber: 4.6g
• Sugar: 7.7g

5. Sweet Potato Black Bean Casserole

Have some dinner guests who follow a plant-based diet and don’t know what to serve them? This vegetarian meal is a mix of sweet, savory, and slightly spicy flavors.

It has sweet potatoes, hearty black beans, and a blend of spices, all layered with tortillas and melted cheddar cheese.

This delicious casserole makes a great Thanksgiving potluck idea!

Per Serving:

• Calories: 492
• Fats: 14g
• Protein: 23g
• Carbs: 71g
• Fiber: 15g
• Sugar: 9g

6. Lazy Lasagna Casserole

Get all the comforting flavors of lasagna without all that time-consuming layering. It’s cheesy, meaty, and packed with 32 grams of protein per serving, making it a hearty and satisfying choice for your holiday meal.

Serve it with a nice green salad to have a complete and balanced meal. And, if you want to boost the protein, who says you cannot add a couple of slices of turkey?

Per Serving:

• Calories: 449
• Fats: 22g
• Protein: 32g
• Carbs: 28g
• Fiber: 3.9g
• Sugar: 9.2g

7. Buffalo Chicken Sweet Potato Casserole

This dish has everything you need to impress your friends and family. It has shredded chicken, tossed with buffalo sauce, layered with roasted sweet potatoes, and topped with cheese to help balance all the flavors.

This casserole offers a creative twist on traditional Thanksgiving flavors.

Per Serving:

• Calories: 443
• Fats: 22g
• Protein: 35g
• Carbs: 29g
• Fiber: 6.8g
• Sugar: 6.5g

8. Taco Casserole

Want to bring the fun of taco night to your Thanksgiving celebration? This has all the elements of a great taco: seasoned ground meat, beans, corn, and cheese. Can you ask for more?

One of the best things about this recipe is that it’s so customizable. Everyone can pick their own toppings, making it a great option for different dietary needs.

Per Serving:

• Calories: 557
• Fats: 32g
• Protein: 32g
• Carbs: 39g
• Fiber: 11g
• Sugar: 7.3g

9. Pizza Pasta Casserole

Combine everyone’s all-time favorites: pizza and pasta. This dish features pasta, marinara sauce, pepperoni, and plenty of melted cheese.

With 27 grams of protein per serving and just a bit over 500 calories, this is a complete meal you can serve those picky eaters.

Per Serving:

• Calories: 526
• Fats: 24g
• Protein: 27g
• Carbs: 50g
• Fiber: 5.3g
• Sugar: 11g

10. Broccoli Cauliflower Casserole

If you want a lighter and low-carb option, this broccoli cauliflower casserole is a great side dish to have with your turkey and mashed potatoes. Each bite gives you broccoli and cauliflower florets, all wrapped in a creamy, cheesy sauce.

This casserole is a great way to get more vegetables onto the Thanksgiving table in a delicious and appealing way.

Per Serving:

• Calories: 388
• Fats: 32g
• Protein: 17g
• Carbs: 12g
• Fiber: 2.4g
• Sugar: 3.6g

11. Teriyaki Chicken Casserole

Add an Asian-inspired twist to your Thanksgiving dinner with this teriyaki chicken casserole. This dish has everything.

It has tender chicken, rice, and a sweet and savory teriyaki sauce. And, it’s all baked together to create a flavorful and satisfying meal.

Per Serving:

• Calories: 428
• Fats: 3.7g
• Protein: 35g
• Carbs: 64g
• Fiber: 2.9g
• Sugar: 20g

12. Meatballs Pasta Casserole

Enjoy the classic comfort of spaghetti and meatballs in a convenient casserole form. This meatball pasta casserole has juicy meatballs, your favorite pasta, a rich tomato sauce, and all topped with melted cheese.

It’s so easy to assemble, and it’s definitely going to be a hit with all your guests (no matter the age).

Per Serving:

• Calories: 369
• Fats: 21g
• Protein: 22g
• Carbs: 21g
• Fiber: 2.7g
• Sugar: 5.6g

13. Chicken Broccoli Bake

This chicken and broccoli bake is a classic comfort food casserole that’s both delicious and nutritious. It combines tender chicken and broccoli florets in a creamy, cheesy sauce, baked until golden and bubbly.

The casserole is a great way to boost your protein and your veggies at the same time.

Per Serving:

• Calories: 354
• Fats: 24g
• Protein: 26g
• Carbs: 8.9g
• Fiber: 2.4g
• Sugar: 2.8g

14. Tex Mex Casserole

Go Tex-Mex in your next Thanksgiving dinner. This dish has a delicious blend of ground meat, beans, corn, and cheese.

This low-calorie option (that still packs 20 grams of protein per serving) is a great side dish if you want to serve something hearty, but without overloading your calories.

Per Serving:

• Calories: 269
• Fats: 14g
• Protein: 20g
• Carbs: 16g
• Fiber: 3.6g
• Sugar: 1.8g

15. Stuffed Pepper Casserole

Who doesn’t love stuffed peppers? But if you need to feed a large group of people, it can be tedious to make every single stuffed pepper.

This casserole gives you all the flavors of stuffed peppers without the fuss of having to stuff each one. The deconstructed stuffed pepper casserole combines ground meat, rice, bell peppers, and delicious tomato sauce.

Per Serving:

• Calories: 386
• Fats: 7g
• Protein: 23g
• Carbs: 35g
• Fiber: 3.3g
• Sugar: 4.6g

16. Keto Chicken Bacon Ranch Casserole

With less than 4 grams of net carbs, this keto chicken bacon ranch casserole is perfect for anyone following a low-carb or keto diet. It’s a rich and savory meal, made with chicken, bacon, and a creamy ranch sauce, all topped with melted cheese.

It’s a decadent yet keto-friendly option that suits any dietary need (even those who are not doing keto are going to love it).

Per Serving:

• Calories: 315
• Fats: 22g
• Protein: 25g
• Carbs: 4.2g
• Fiber: 0.9g
• Sugar: 1.8g

17. Keto Jalapeno Popper Casserole

Bring some heat to your holiday table with this keto jalapeño popper casserole. This dish has all the spicy, creamy, and cheesy goodness of the classic jalapeño popper but in a convenient casserole format.

This is a great option for those who love bold, spicy flavors.

Per Serving:

• Calories: 438
• Fats: 31g
• Protein: 34g
• Carbs: 5.4g
• Fiber: 0.6g
• Sugar: 2.1g

18. Chicken Bacon Ranch Casserole

Source: wholesomeyum.com

Looking for a way to elevate your meal? This chicken bacon ranch casserole is creamy and flavorful.

It’s made with tender chicken, crispy bacon, and a rich ranch sauce that blends everything together. It’s perfect if you are looking for a great low-carb side dish.

Per Serving:

• Calories: 447
• Fats: 35.8g
• Protein: 37.3g
• Carbs: 6g
• Fiber: 1.6g
• Sugar: 1.3g

19. Chicken and Butternut Squash Biscuit Casserole

Source: neighborfoodblog.com

Want something a bit more fall-related? This chicken and butternut squash biscuit casserole is a cozy meal waiting for you to try it.

Here, you get tender chicken and sweet butternut squash, all coated in a delicious creamy sauce. And, if that was not enough, it’s topped with fluffy biscuits.

Per Serving:

• Calories: 383
• Fats: 15g
• Protein: 23g
• Carbs: 40g
• Fiber: 4g
• Sugar: 6g

21. Sweet Potato and Ground Beef Casserole

Source: theroastedroot.net

This sweet potato and ground beef casserole is a savory (but slightly sweet) dish that packs 30 grams of protein per serving. It layers seasoned ground beef with mashed sweet potatoes for a hearty and nutritious meal.

The natural sweetness of the sweet potatoes complements perfectly the ground beef, creating a balanced and delicious meal.

Per Serving:

• Calories: 455
• Fats: 20g
• Protein: 30g
• Carbs: 38g
• Fiber: 4g
• Sugar: 7g

22. Ground Turkey Pasta Bake

Source: ifoodreal.com

This casserole combines lean ground turkey, pasta, and kale in a savory tomato sauce, all baked with a cheesy topping. It gives you 28 grams of protein per serving, making it a healthy and satisfying option.

And, it’s so easy to make that it will melt your holiday stress away.

Per Serving:

• Calories: 348
• Fats: 9g
• Protein: 28g
• Carbs: 39g
• Fiber: 5g
• Sugar: 6g

23. Wild Rice Chicken Casserole

Source: theroastedroot.net

If you are looking for a gluten-free option, this wild rice chicken casserole is the best option. It features a creamy blend of wild rice, tender chicken, and mushrooms.

The nutty flavors of the mushrooms and the rice create a rustic, elegant dish. And, nobody will believe that it took you less than an hour to make.

Per Serving:

• Calories: 379
• Fats: 16g
• Protein: 23g
• Carbs: 29g
• Fiber: 4g
• Sugar: 5g